Copper-catalyzed domino intramolecular cyclization: a facile and efficient approach to polycyclic indole derivatives.
نویسندگان
چکیده
A mild and efficient Cu(2)O-catalyzed domino intramolecular C-N coupling/C-Y (Y = O, S, N) bond formation was successfully achieved. Thus oxazino[3,2-a]indole, thiazino[3,2-a]indole and indolo[2,1-b]quinazoline derivatives were facilely assembled from readily accessible gem-dibromovinyl systems. The protocol is general and practical, affording a variety of the indole-incorporated products in good to excellent yields even under air atmosphere.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 8 شماره
صفحات -
تاریخ انتشار 2012